منابع مشابه
Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF randomized trial.
IMPORTANCE Prevention strategies for heart failure are needed. OBJECTIVE To determine the efficacy of a screening program using brain-type natriuretic peptide (BNP) and collaborative care in an at-risk population in reducing newly diagnosed heart failure and prevalence of significant left ventricular (LV) systolic and/or diastolic dysfunction. DESIGN, SETTING, AND PARTICIPANTS The St Vincen...
متن کاملSTOP-HF: Expanding the role of HF programs into the community
The St Vincent's Screening TO Prevent Heart Failure (STOP-HF) study is a recently published trial that assessed the use of brain natriuretic peptide (BNP) as a screening tool for HF in an at-risk population in reducing newly-diagnosed heart failure and prevalence of significant left ventricular (LV) systolic and/or diastolic dysfunction. The study provides an excellent model to the global commu...
متن کاملThe AVOID-HF Trial: Points to Consider.
The large-scale AVOID-HF (Aquapheresis Versus Intravenous Diuretics and Hospitalization for Heart Failure) trial compared ultrafiltration and medical treatment in acute heart failure (HF) (1). A major advantage of this study was the use of adjustable, rather than fixed, treatment regimens in both arms. The study was terminated early but still could demonstrate a nonsignificant trend for longer ...
متن کاملGeographic variations in the PARADIGM-HF heart failure trial
AIMS The globalization of clinical trials has highlighted geographic variations in patient characteristics, event rates, and treatment effects. We investigated these further in PARADIGM-HF, the largest and most globally representative trial in heart failure (HF) to date. METHODS AND RESULTS We looked at five regions: North America (NA) 602 (8%), Western Europe (WE) 1680 (20%), Central/Eastern...
متن کاملPARADIGM-HF Trial and its Important Clinical Meanings
ACEi/ARB and ß blocker and aldosterone antagonist have been a gold standard for treating chronic heart failure with reduced ejection fraction (HFrEF). The paper described simply the PARADIGM-HF study (Prospective comparison of ARNi with ACEi to Determine Impact on Global Mortality and morbidity in HF trial), and the results showed that compared to enalapril, LCZ69(ARNi) significantly reduced th...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2021
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2021.05.001